Reviews all the known tumor suppressor genes, explains how they work, and describes how they were discovered and isolated. In many cases, the authors discuss specific genes that are frequently involved in hereditary or sporadic cancers. They also provide a detailed guide to using powerful molecular genetic, cytogenetic, proteomic, and cell biological strategies to discover and isolate novel tumor suppressor genes and their targets. The second volume of this two-volume set, Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medical Applications, shows how to explore the cell biology and biochemical function of such encoded proteins, to study its physiological role in vivo, and to use information on TSGs to develop diagnostic and therapeutic strategies for cancer.ACT Laboratory Manual, pp. 38a62. 2. ... (1992). Cytogenetic analysis by chromosome painting using DOP-PCR amplified flow-sorted chromosomes. ... Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors.
|Title||:||Tumor Suppressor Genes|
|Author||:||Wafik S. El-Deiry|
|Publisher||:||Springer Science & Business Media - 2003-01-01|