Tumor Antigens Recognized by T Cells and Antibodies

Tumor Antigens Recognized by T Cells and Antibodies

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Recent progress in fundamental tumor immunology has led to immunotherapy trials in patients with solid tumors and hematological malignancies. In the past, immunotherapy approaches were primarily based on enhancement of tumor immunity with cytokines and adjuvant therapy, without knowledge of relevant tumor antigens. The discovery of tumor antigens capable of eliciting immune responses has now resulted in the development of antigen-specific immunotherapy strategies. Vaccination with defined peptide epitopes, purified proteins, cell components, and whole cells expressing defined tumor antigens provides an opportunity to measure antigen-specific immune responses in vaccinated patients, and to correlate immunity with clinical outcome. Tumor Antigens Recognized by T Cells and Antibodies provides a comprehensive overview of the molecular nature of tumor antigens that can be recognized by antibodies, helper T lymphocytes and cytotoxic T lymphocytes. Novel strategies to enhance ineffective immunity against such antigens provide the basis for improved immunotherapy protocols for patient treatment. With contributions from a host of international experts in the field, this book provides invaluable information for clinicians and researchers with an interest in cancer immunotherapy.Among them, at least seven (i.e. MAGE- A1, -A2, -A3, -A4, -A6, -A10 and -A12) encode T-cell defined epitopes that are presented by HLA class ... it/menurisorse/ listing/pdf/tables%201a€“7.pdf). ... suggested by the observation that some cancer patients produce anti-MAGE IgG antibodies in vivo (Sahin et al., 1995) and indeed, anbsp;...

Title:Tumor Antigens Recognized by T Cells and Antibodies
Author:Hans J Stauss, Yutaka Kawakami, Giorgio Parmiani
Publisher:CRC Press - 2003-01-23


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