High-fidelity chromosomal DNA replication underpins all life on the planet. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Building on recent exciting advances in protein structure determination, the book will take the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosome replication and provide an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective.J Biol Chem 286:11855a11864 Guillou E, Ibarra A, Coulon V, Casado-Vela J, Rico D, Casal I, Schwob E, Losada A, Mendez J (2010) ... Genes Dev 24:2812a 2822 Hanson PI, Whiteheart SW (2005) AAA+ proteins: have engine, will work. Nat Rev ... Nucleic Acids Res 21:2541a2547 Kubota Y, Takase Y, Komori Y, Hashimoto Y, Arata T, Kamimura Y, Araki H, Takisawa H (2003) A novel ring-like complex ofanbsp;...
|Title||:||The Eukaryotic Replisome: a Guide to Protein Structure and Function|
|Publisher||:||Springer Science & Business Media - 2012-08-23|