This dissertation also provides insight for ligand interaction toward alpha7 nAChR through homology model of mouse alpha7 nAChR. For rational PET tracer design, a quantitative structure-activity relationship study was performed to provide a putative ligand candidate for alpha7 nAChR.... 30-40 g) were imaged with small animal PET (MicroPET R4 TM, Siemens) after the injection of 2-11C-2 or 4-11C-2; ... List mode data was binned into a maximum of 22 frames (5x2 sec, 10x5 sec, 7 x 300 sec) using microPET Manager (v.
|Title||:||Synthesis and Positron Emission Tomography Studies of Radioligands Targeting Alpha7 Nicotinic Acetylcholine Receptors in the Central Nervous System|
|Author||:||Sung Won Kim|
|Publisher||:||ProQuest - 2007|