The next two chapters (Chapters 2 and 3) describe our efforts towards isolating Ru-based NO donors that are sensitive to visible light, instead of UV light. Such complexes are potentially much more useful in biological NO transfer experiments, or as potential therapeutics in photodynamic therapy (PDT). One major focus has been the direct coordination of visible-light-harvesting chromophores to the Ru-center, which has aided in photosensitizing Ru-nitrosyls up to wavelengths of 600 nm (red light).Conclusions The quest for a ruthenium nitrosyl that could photodeliver NO to biological targets on demand has produced interesting and encouraging results so far ...  P.G. Wang, M. Xian, X. Tang, X. Wu, Z. Wen, T. Cai, A.J. Janczuk, Chem.
|Title||:||Syntheses, X-ray Structures, Spectroscopy, DFT Electronic Configuration, and Biological Relevance of Photolabile Ruthenium and Iron Nitrosyls Derived from Ligands Containing Carboxamido-N Donors|
|Author||:||Michael J. Rose|
|Publisher||:||ProQuest - 2009|