High-performance liquid chromatography (HPLC) following acid/ alkaline exposure of the peptide and enzymatic ... of the functional amino acids all of which are levorotatory (L) except for the Leu in position 6 which is dextrorotatory ( D). ... of the NH2-terminal amino acid (p-Glu) and amide formation in the case of the COOH-terminal amino acid (Pro-ethylamide). ... are inconsequential to ionization techniques as are the numerous purification steps associated with manual degradation ofanbsp;...
|Title||:||Stability and Characterization of Protein and Peptide Drugs|
|Author||:||Rodney Pearlman, Y. John Wang|
|Publisher||:||Springer Science & Business Media - 2013-06-29|