Radiolabeled Monoclonal Antibodies for Imaging and Therapy

Radiolabeled Monoclonal Antibodies for Imaging and Therapy

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The advent of hybridoma technology leading to the successful produc tion of monoclonal antibodies against a variety of tumor-associated antigens has, during the last decade, provided a very powerful tool for research and clinical investigations. These highly specific reagents have essentially replaced the polysera of the earlier days. The successful demonstration of the many wide ranging capabilities of the monoclonal antibody technique has already begun to exert an enormous impact on diverse areas of research in basic science and medicine. In particular, the potential of monoclonal antibodies to serve as carriers for selective targeting of radionuclides to tumors for diagnosis or therapy, has stimulated an intense surge of research interest and even revived hopes of realizing Ehrlich's concept of the qmagic bulletq. Indeed, the technology appears to be on the threshold of a revolution in diagnosing and treating malignant disease. Much work remains to be done, however, and even though the progress has been impressive, results to date have shown only moderate success. There is no question that the limited success we have achieved thus far is merely a prelude to the many more exciting developments yet to come.Carras quillo JA, Krohn K.A., Beaumier P, McGuffin Rw, Brown JP, Hell strom KE Hell strom I, and Larson SM . Diagnos is and therapy for solid tumors with radio labeled antibodies and immune fragments. Cancer Treat Rep 68: 317a€“328 ... Snyder WS, Ford MR, and Warner GG. Estimates of ... MIRD Pamphlet No 1 1, Society of Nuclear Medicine, 1975 . Berman M and we iss MF. SAAM Manual. US DHEWanbsp;...

Title:Radiolabeled Monoclonal Antibodies for Imaging and Therapy
Author:Suresh C. Srivastava
Publisher:Springer Science & Business Media - 2013-03-14


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