In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.Protein Sci 2:877a883 Coates L, Erskine PT, Mall S et al (2006) X-ray, neutron and NMR studies of the catalytic mechanism of aspartic ... J Antibiotics 23:259a 262 Koelsch G, Mares M, Metcalf Petal (1994) Multiple functions of pro-parts of aspartic proteinase zymogens. ... Crit Rev Biochem Mol Biol 38:89a119 Cooper JB (2002) Aspartic proteinases in disease: a structural perspective. ... J Med Chem 43:305a341 Abbenante G, Fairlie DP (2005) Protease inhibitors in the clinic.
|Title||:||Proteases in Health and Disease|
|Author||:||Sajal Chakraborti, Naranjan S. Dhalla|
|Publisher||:||Springer Science & Business Media - 2013-12-04|