The 2-stage GBTBM simulated the surface area and the flow Reynolds number of the trachea, main, lobar and segmental bronchi of the human lung. Its major advantage with the ACI was its ability to simulate all five electromechanical deposition mechanisms of aerosols while the stages cutoff diameters are equal to the 3rd and the 4th stages of the ACI. The deposition of unipolarly charged particles on the OPL airways is about three times of the bipolarly charged particles. Modeling studies with CM revealed that by enhancing electrostatic charge 1.5 times, improvement in the deposition of drug aerosols in the respiratory airways can be achieved, which will compensate 67% of the reduction due to the absence of gravity.The charger was connected to an aerosol holding chamber (AHC) with dimensions of 21 cm x 18 cm x 21 cm (LxWx H). Its performance was well reported elsewhere (Adamiak, 2002; Dalley et al. 2005). Figure 3.3 shows the schematic diagramanbsp;...
|Title||:||Physical and Computational Models of Human Lung for Optimizing Respiratory Drug Delivery|
|Publisher||:||ProQuest - 2008|