This book reviews the electrophysiological, genetic and immunological bases of some of the major neuromuscular diseases and evaluates their importance pertaining to the clinical management of the patients. Included are up-to-date topics such as gene therapy, myoblast transfer and new drug trials. Written by experts in their own fields, this volume will not only be of great value to neurologists and neuroscientists, but also to geneticists, immunologists and physiologists.The first step in understanding the molecular basis of genetic myopathies was the discovery of the molecular cause of Duchenne muscular dystrophy ... During adult life, precursor myogenic cells (called satellite cells) are quiescent in the periphery of mature myofibres . When a myofibre is damaged, satellite cells proliferate and fuse to repair the damaged segment or replace it altogether .
|Publisher||:||Karger Medical and Scientific Publishers - 2000-01-01|