Nature Reviews

Nature Reviews

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KPI COOH PS1/PS2 and APPTM mutations Degradation/removal (LRP/RAGE/ A2M/insulin- degrading enzyme (IDE)/neprilysin?) Neurotoxicity Figure 2 | Schematic of the proteolytic events and cleavage products that are $ during the processing of APR The amyloid ... because of the role of ApoE in lipid metabolism and repair mechanisms, it is conceivable that the e4 allele might not support theseanbsp;...

Title:Nature Reviews
Publisher: - 2002


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