Knowledge of cardiac ion channels and transporters has advanced remarkably in the last two decades with the development of patch-clamp and molecular biological techniques. This textbook offers a comprehensive overview of structures and functions of ion channels and transporters in the heart. Readers are first introduced to the molecular biology and electrophysiology of all the important ion channels. After discussing their developmental changes, the pharmacology and pathophysiology of clinically-relevant ion channels are reviewed. Molecular aspects of the cardiac excitation-contraction coupling and intracellular Ca2+ regulation by ion transporters are also described. The book will be useful to electrophysiologists, cardiac physiologists and pharmacologists, and molecular biologists interested in ion channels at all levels. For research specialists, the book will provide a perspective of the field. The book can be used as a reference source for working scientists in the fields of ion channels, biophysics, cardiac electrophysiology, and pharmacology. It is aimed at graduate and medical students, designed for use as a textbook for graduate and medical courses.B. Diagram showing the relative location of the exons found in the rabbit genomic clone L211 and the organization of the rabbit brain cDNA clone RB11. The diagram shows how the black-filled boxes (representing the exons and labeled withanbsp;...
|Title||:||Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters|
|Author||:||M. Morad, S. Ebashi, W. Trautwein, Yoshihisa Kurachi|
|Publisher||:||Springer Science & Business Media - 2012-12-06|