Modular Protein Domains

Modular Protein Domains

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Since the full functionality of any given protein can only be understood in terms of its interaction with other, often regulatory proteins, this unique reference source covers all relevant protein domains, including SH2, SH3, PDZ, WW, PTB, EH, PH and PX. Its user-oriented concept combines broad coverage with easy retrieval of essential information, and includes a special section on Web-based tools and databases covering protein modules and functional peptide motifs. Essential for the study of protein-protein interactions in vivo or in silico, and a prerequisite for successful functional proteomics studies. With a prologue by Sir Tom Blundell.Many SAP mutations cause substitutions in the SH2 domain, resulting in either a loss of binding to SLAM or protein destabilization (or both) (Figures 1.6 ... proteins stimulate the Ras-MAP kinase and PI 3a€² kinase pathways, in a fashion that correlates with malignancy [182]. ... (a) Schematic of the Bcra€“Abl tyrosine kinase.

Title:Modular Protein Domains
Author:Giovanni Cesareni, Mario Gimona, Marius Sudol, Michael Yaffe
Publisher:John Wiley & Sons - 2006-03-06


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