Mechanisms of DNA Damage and Repair

Mechanisms of DNA Damage and Repair

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This book is based on the papers presented at the conference on qMecha nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment, q held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; drugs which bind selectively to altered and potentially damaging DNA sequences; and potential utilization of DNA damage as an endpoint for assessing risks of UV light, ionizing radiations, chemicals, drugs, and hazardous agents in foods. Because the induction of mutations by radiation and genotoxic chemicals has been observed to follow one-hit kinetics in some instances, it is generally assumed that any level of exposure to a DNA-damaging agent may increase the risk of genetic disease or cancer in an exposed population. At the same time, however, there is evidence that although the DNA of living cells is continually damaged by natural background radiation, free radicals, and other naturally occurring processes, most of the damage is normally repaired.The city was just putting in sidewalks and the town did not make a very modern impression. So, I decided to ... of modern biology. The emphasis of the program was on genetics which I felt to be the keystone in modern biology. ... The fundamental work was on bacteria, plants (Maize, Trades ... A good head start in this investigation was gained by taking on the mice surviving the Bikini test in the Pacific.

Title:Mechanisms of DNA Damage and Repair
Author:Michael G. Simic, Lawrence Grossman, Arthur C. Upton, David S. Bergtold
Publisher:Springer Science & Business Media - 2013-11-21


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