Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics. Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: HPLCahigh-resolution mass spectrometry for quantitative assays Mass spectrometry for siRNA Quantitative analysis of peptides Mass spectrometry analysis of biological drugs Applications that support medicinal chemistry investigations Mass spectrometry imaging and profiling Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field. Mass Spectrometry for Drug Discovery and Drug Development is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.On the other hand, the most distinct feature of HPLC-HRAMS is its ability to detect not only all the ions (protonated, sodium, or ammonium adducted, etc ... The accuracy of the area value obtained for the target analyte chromatographic peak in the EIC is dependent on using the optimum MEW ... about other compounds of interest in the sample (e.g., metabolites) and for troubleshooting analytical problems.
|Title||:||Mass Spectrometry for Drug Discovery and Drug Development|
|Author||:||Walter A. Korfmacher|
|Publisher||:||John Wiley & Sons - 2012-12-12|