Manipulation of the host cell by viral auxiliary proteins

Manipulation of the host cell by viral auxiliary proteins

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Productive HIV infection requires completion of all the steps of the replication cycle, the success of which largely relying on the multiple interactions established by viral proteins with cellular partners. Indeed, cellular and viral fates are intertwined and this interplay may involve rerouting of cellular factors/pathways to the benefit of the viral life cycle. To gain a foothold into host cells, HIV has to take advantage of available cellular factories and overcome the numerous potential blocks opposed to its replication while ensuring cellular survival. Viral auxiliary proteins are a perfect paradigm to illustrate the complexity of the relationship between HIV and its host. Although these accessory proteins are mostly unnecessary for viral replication in permissive cells in vitro, they play a crucial role in regulating viral spread ex vivo in non-permissive cells and in vivo in hosts. Most accessory proteins are pleiotropic and instrumental in the counteraction of restriction factors and proteins involved in innate immune response. Several proteins of the a€œintrinsica€ immune system that detect the presence of the assailant and initiate a subsequent immune response, as well as restriction factors that are directly devoted to arresting the replication cycle at precise steps have been characterized. Despite the numerous cellular mechanisms dedicated to preventing viral replication, HIV is able to efficiently replicate in humans. Indeed, as a master regulator of cellular machineries and processes, not only has HIV evolved strategies to avoid triggering of pattern recognition receptors, but HIV has also elaborated ways to counteract host restriction factors, thereby overcoming the hurdles that oppose efficient replication. This review collection is dedicated to the manipulation of host cells by HIV-1 and HIV-2, with a particular focus on viral accessory proteins.The discovery of the SLX4 complex as being involved in inhibition of pro- inflammatory responses opens new ... damage repair mechanisms may be involved in pathogen recognition and inhibition of spontaneous pro-inflammatory cytokine production. ... E03- 08-0580 Boddy, M. N., Gaillard, P. H., McDonald, W. H., Shanahan, P., Yates, J. R. III, and Russell, P. (2001). ... 22, 906a€“912. doi: 10.1016/j.semcdb.2011.07.001 Chan, K. L., Palmai-Pallag, T., Ying, S., and Hickson, I. D. (2009).

Title:Manipulation of the host cell by viral auxiliary proteins
Author: Nadine Laguette, Monsef Benkirane
Publisher: - 2015-05-07


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