This book aims to provide an up-to-date review of the literature in each of the major areas relating to the management of older lung cancer patients, and makes recommendations for best practice and future research. The authors come from a broad geographic spread including the UK, mainland Europe and North America to ensure a worldwide relevance.Several studies, using cytologic and molecular techniques, have established that cigarette smoking creates injury in all airway ... leads to dysregulated repair by stem/progenitor cells, which form a clonal group of indefinitely self-renewing daughter cells. ... Development of an expanding premalignant field appears to be a critical step in lung carcinogenesis that can persist even after smoking cessation.
|Title||:||Management of Lung Cancer in Older People|
|Author||:||Cesare Gridelli, Riccardo A. Audisio|
|Publisher||:||Springer Science & Business Media - 2013-04-15|