While we generally eat infrequently, metabolic processes within our body tightly regulate blood glucose levels. The metabolic system is comprised of various tissues, each of which contains specific regulatory pathways that determine the function of the tissue within the system. These tissues and their localized metabolic functions, complement one another through inter-tissue metabolic highways to form the entire metabolic system. The liver is a key control center of metabolism and thus, the mathematical model described in this thesis is heavily 'liver-centric.' Though all hepatocytes, or liver cells, are capable of similar metabolic functions, the rate at which these functions are carried out depends on the location of the hepatocytes within the liver. At the intracellular level, the various metabolic pathways contain many intersections. Though the intracellular components of the metabolic system are spatially localized, I assume a well-mixed cell and ignore spatial heterogeneity.A diagram of glycogenolysis is shown in Figure 2.3. 2.3.4 Glycogenolysis Using glycogen as a source of glucose is the fastest pathway to regulate when blood glucose levels drop and a supply of glucose is needed immediately. Just asanbsp;...
|Title||:||Inclusion of a Glycogen Regulation Mathematical Model Into a Contextual Metabolic Framework|
|Author||:||Abby Jo Todd|
|Publisher||:||ProQuest - 2008|