The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a toll booth. In order to break the bottleneck, a corresponding revolutionary improvement to the conventional methodology must happen.... (MALDI) accuracy of, 333a334 description of, 380 vs. ESI, 333 in imaging mass spectrometry, 385 for macromolecules, 333a334 plate readers and, 94 process diagram, 381 for sampling, 139 ToFMS and, 333, 356, 382 Matrix effect in APCI, 220 definition of, 220 in dissolution testing, 271 in ESI, 220 in HPLC, 212, 220, 222 ion suppression from, 220 measurement of, 220 in PPT, 212, anbsp;...
|Title||:||High-Throughput Analysis in the Pharmaceutical Industry|
|Author||:||Perry G. Wang|
|Publisher||:||CRC Press - 2008-08-20|