Hepatic cells are involved in the metabolization and elimination of a variety of endogenous and exogenous substances. They mediate the uptake, processing and subsequent secretion of biliary compounds, such as various drugs or hormones, and the passage of metabolites to be released into different blood compartments. To perform vectorial passages hepatocytes show a strong polarity with sites for endocytotic processes or specific carrier molecules, and a specified system of organelles for intracellular transport and sorting, metabolization and secretion of compounds. Several aspects, e.g. regulation, control and mechanisms of hepatic traffic are reported in detail - complemented by methodological approaches to analyse and monitor these processes.Diagram of thyroid hormone physiology. Indication of the efficiency of deiod in at ion is based on determinations of de iodinase activities in tissues from euthyroid rats. Another metabolite of T4 is 3, 3a#39;, 5a#39;-triiodothyronine (rT3). The metabolism ofanbsp;...
|Title||:||Hepatic Transport of Organic Substances|
|Author||:||Ernst Petzinger, Rolf K.H. Kinne, Helmut Sies|
|Publisher||:||Springer Science & Business Media - 2012-12-06|