The cloning, sequencing, and expression of a variety of membrane receptors and channels indicate the existence of at least four qsuperfamiliesq of molecular structures that mediate signal transduction. Presently, more than 400 receptors have been cloned and sequenced. The Handbook of Receptors and Channels is the first handbook series to present the enormous amount of new molecular biological receptor data in a practical and useful format. Each volume in this remarkable series will focus on a specific molecular superfamily of receptors. Complete amino acid sequence information on all cloned receptors, as well as relevant pharmacological information, will be included. Furthermore, the format for each of the volumes will be consistent to allow for easy comparisons of different molecular subtypes for a given transmitter. G Protein-Coupled Receptors is the first volume in this new handbook series. Topics covered in future volumes include:... Receptor messenger cloned location Sequence number Primary reference Alpha 1A +PI Human 5q23-32 501 P25100 Bruno et al., ... Cotecchia et al., 1988 Alpha 1C +PI Bovine 466 P18130 Schwinn et al., 1990 Alpha 2A aAC Human 10q24-26 450 P08913 Kobilka et ... Kobilka et al., 1987 Hamster 418 PO4274 Dixon et al., 1986 Rat 418 P10608 Gocayne et al., 1987 Mouse 418 P18762 Allen et al., anbsp;...
|Title||:||Handbook of Receptors and Channels|
|Author||:||Stephen J. Peroutka|
|Publisher||:||CRC Press - 1993-10-20|