Handbook of Carcinogenic Potency and Genotoxicity Databases

Handbook of Carcinogenic Potency and Genotoxicity Databases

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This unique new reference contains the Carcinogenic Potency Database (CPDB), which analyzes results of decades of animal cancer tests, including all Technical Reports of the National Toxicology Program (NTP) and the general published literature. A guide to the literature of animal cancer tests, the CPDB includes references to each published experiment and never-before published analyses. For each of 5, 000 long-term experiments on 1, 300 chemicals, the user-friendly format includes data on the species, strain, and sex of the test animal; features of experimental protocol such as the route of administration, duration of dosing, dose levels, and duration of the experiment; histopathology and tumor incidence; the shape of the dose-response curve; published author's opinion about the carcinogenicity at each site; and reference to the original publication of the test results. In addition, a measure of carcinogenic potency, the TD50, its statistical significance and confidence limits, are given for each tumor site. An overview is provided of earlier publication updates, such as positivity rates, reproducibility, interspecies extrapolation, and ranking possible carcinogenic hazards. The book also includes a summary of the NTP genetic toxicity test results on 1, 500 chemicals, which are referenced to the original publications, including the Salmonella (Ames) test, L5178Y mouse lymphoma cell mutation test, chromosome aberration and sister chromatid exchange tests in cultured Chinese hamster ovary cells, and the sex-linked recessive lethal mutation test in Drosophila melanogaster. An index with chemicals listed by CAS number allows cross referencing between the carcinogenicity and genotoxicity databases, making data easy to find.The Chemical Abstracts Service registry number (CAS#) is reported under (18) in the example, 10693-4. ... Results in Chapter 5, Section B. (19) Under the header a€œ RefNuma€ in (19), is the unique reference number assigned to each paper in the database. ... downward departure from linearity), we have indicated this fact with parentheses around the data which were omitted from the final calculation.

Title:Handbook of Carcinogenic Potency and Genotoxicity Databases
Author:Lois Swirsky Gold, Errol Zeiger
Publisher:CRC Press - 1996-11-26


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