Gene transfer to animal cells was first achieved more than thirty years ago. Since then, transformation technology has developed rapidly, resulting in a multitude of techniques for cell transformation and the creation of transgenic animals. As with any expanding technology, it becomes difficult to keep track of all the developments and to find a concise and comprehensive source of information that explains all the underlying principles. Gene Transfer to Animals Cells addresses this problem by describing the principles behind gene transfer technologies, how gene expression is controlled in animal cells and how advanced strategies can be used to add, exchange or delete sequences from animal genomes in a conditional manner. A final chapter provides an overview of all the applications of animal cell transformation in farming, medicine and research.The CID system has already been described as a transcriptional switch, in which separate DNA-binding and transactivation domains expressed as ligand-binding fusion proteins ... In: Sambrook J, Fritsch EF, Maniatis T (eds) Molecular Cloning aA Laboratory Manual (second edition), pp. ... Hager LJ, Palmiter RD (1981) Transcriptional regulation of mouse liver metallothionein I gene by glucocorticoids.
|Title||:||Gene Transfer to Animal Cells|
|Publisher||:||Garland Science - 2004-04-01|