Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix a secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.The maintenance of thinning in the animal cap region and marginal zone regions of the BCR requires FN (Boucaut et al. 1985; Johnson et al. 1993; Davidson et al. 2006; Marsden and DeSimone 2001; Rozario and DeSimone 2010). The initialanbsp;...
|Title||:||Extracellular Matrix in Development|
|Author||:||Douglas W. DeSimone, Robert Mecham|
|Publisher||:||Springer Science & Business Media - 2013-03-15|