The objectives of the studies presented in this dissertation were: (a) to evaluate the selective 5-HT2A receptor blocker ketanserin and the nonselective 5-HT1/2 receptor blocker methiothepin in the pulmonary hypertensive responses of broilers to i.v. infused 5-HT; (b) to evaluate the pulmonary hypertensive responses of broilers to i.v. injected bacterial lipopolysaccharide (LPS) and microparticles after treatment with the 5-HT receptor blocker methiothepin. Both microparticles and LPS are capable of eliciting a powerful inflammatory response and triggering pulmonary vasoconstriction when injected i.v. in broilers; and (c) to analyze plasma 5-HT levels and hemodynamic responses in broilers challenged with LPS and microparticles following chronic 5-HT infusion via osmotic pumps.Brade, H., S. M. Opal, S. N. Vogel and D. C. Morrison, editors. 1st ed. Marcel Dekker, Inc. New York. Hussain, I., and M. A. Qureshi. ... Immunol. Immunopathol. 61:317-329. Jandel Scientific. 1994. SigmaStat Statistical Software Usera#39;s Manual.
|Title||:||Evaluation of the Role of Serotonin in Pulmonary Arterial Hypertension in Broilers Induced by Bacterial Lipopolysaccharide and Cellulose Microparticles|
|Publisher||:||ProQuest - 2007|