DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics include carcinogenesis as a predictive and/or prognostic biomarker for cancer therapy, nucleotide excision repair, and tumor genetics and personalized medicine. The contributions provide essential information to scientists, pharmaceutical investigators, and clinicians interested in cancer therapy.2005; Farmer et al. 2005; Hegan et al. 2010), and this special case in relation to hypoxic cells is discussed in detail below. Data pertaining to the function of the NHEJ pathway indicate that it is either unchanged (Menget al. 2005) or possiblyanbsp;...
|Title||:||DNA Repair and Cancer|
|Author||:||Srinivasan Madhusudan, David M. Wilson III|
|Publisher||:||CRC Press - 2013-01-22|