Estrogenic endocrine disrupting chemicals (EEDCs) are a growing matter of concern in the etiology of several developmental, reproductive and general health related adverse health effects. These include breast cancer, decreasing fertility rates, and birth defects. These chemicals are structurally diverse and arise from a broad range of sources including natural products, pesticides, food processing and packaging materials, and pharmaceuticals. These chemicals mediate most of their effects through estrogen receptors (ERs) which are ligand-dependant transcription factors. Thus the main mechanism of estrogen signaling involves the regulation of expression of target genes. A major consideration in ER signaling is selective estrogen receptor modulator (SERM) activity, which consists of differential activation of the ER depending upon ligand-specific conformational changes and subsequent transcriptional activities of the activated ER. Thus understanding the activity of SERMs is an essential part of our assessment of EEDCs.Four-Way Venn Analysis - Following pair- wise comparisons by chemical and species, an integrated comparison of all four ... orthologous genes (NCBI, HomoloGene) for each data set were entered into the 4-way Venn Diagram Generator.
|Title||:||Cross-species Comparison of Estrogenic Endocrine Disruptor-induced, Uterotrophic Gene Expression in the Rodent|
|Author||:||Joshua Caleb Kwekel|
|Publisher||:||ProQuest - 2008|