Co-Existence and Co-Release of Classical Neurotransmitters

Co-Existence and Co-Release of Classical Neurotransmitters

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Dale's Principle postulated that a neuron functions as a metabolic unit, whereby a process occurring in the cell can influence all of the compartments of that given neuron. This was unfortunately transformed in the literature to a principle stating that a€œa single cell releases only one neurotransmittera€. Until recently, this has influenced many neuroscientists to consider with skepticism the idea that classical neurotransmitters could be co-released from neurons. It is now clear that the a€œone neuron, one neurotransmittera€ postulate is the exception rather than the rule. The aim of this book is to gather the available evidence, provided by the authors that have discovered and studied the co-existence or co-release of several pairs of neurotransmitters, in several neural networks. It will provide a timely overview of a mechanism of neural communication that is likely to attract increasing attention of the neuroscientific community.As a result of their varying capabilities to stimulate these pathways, combinations of coactive transmitters can achieve a ... While the L-cell and the GPR neurons can exert strong effects on the motor circuits that they regulate, their activity is not anbsp;...

Title:Co-Existence and Co-Release of Classical Neurotransmitters
Author:Rafael Gutierrez
Publisher:Springer Science & Business Media - 2008-12-16


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