Dale's Principle postulated that a neuron functions as a metabolic unit, whereby a process occurring in the cell can influence all of the compartments of that given neuron. This was unfortunately transformed in the literature to a principle stating that aa single cell releases only one neurotransmittera. Until recently, this has influenced many neuroscientists to consider with skepticism the idea that classical neurotransmitters could be co-released from neurons. It is now clear that the aone neuron, one neurotransmittera postulate is the exception rather than the rule. The aim of this book is to gather the available evidence, provided by the authors that have discovered and studied the co-existence or co-release of several pairs of neurotransmitters, in several neural networks. It will provide a timely overview of a mechanism of neural communication that is likely to attract increasing attention of the neuroscientific community.As a result of their varying capabilities to stimulate these pathways, combinations of coactive transmitters can achieve a ... While the L-cell and the GPR neurons can exert strong effects on the motor circuits that they regulate, their activity is not anbsp;...
|Title||:||Co-Existence and Co-Release of Classical Neurotransmitters|
|Publisher||:||Springer Science & Business Media - 2008-12-16|