Chromosomal Translocations and Oncogenic Transcription Factors

Chromosomal Translocations and Oncogenic Transcription Factors

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Regulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. The key players in these processes are sequence-specific DNA binding transcription factor proteins which coordinate programs of gene expression in the nucleus. The articles in this volume document the myriad of genetic and biochemical alterations sustained by human proto-oncogenic transcription factors which result in diverse neoplastic processes. This volume gives insights into how normal programs of gene expression can be subverted by the action of single transcription factors resulting in a specific tumor type. The book provides inspiration for exploiting these tumor-specific alterations as diagnostic, prognostic tools, or as selective therapeutic targets.Am J Pathol 143: 1294a€“1300 Dunn T, Praissman L, Hagag N and Viola MV ( 1994) ERG gene is translocated in an Ewinga#39;s ... Leiden JM and Thompson CB ( 1994) The FLI-1 and chimeric EWS-FLI-1 oncoproteins display similar specificities. ... EWS gene, involved in Ewing family of tumors, malignant soft parts and desmoplastic small round cell tumors, codes for binding ... Diagn Mol Pathol 2: 147a€“157 Taylor C, Patel K, Jones T, Kiely F, De Stavola BL and Sheer D (1993) Diagnosis ofanbsp;...

Title:Chromosomal Translocations and Oncogenic Transcription Factors
Author:Frank J. III Rauscher, Peter K. Vogt
Publisher:Springer Science & Business Media - 2012-12-06


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