Biomaterials as Stem Cell Niche

Biomaterials as Stem Cell Niche

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Recent developments in stem cell biology have opened new directions in cell therapy. This book provides the state-of-the-art developments in using biomaterials as artificial niches for engineering stem cells, both for the purpose of better understanding their biology under 3D biomimetic conditions as well as for developing new strategies for efficient long term maintenance and directed differentiation of stem cells into various therapeutic lineages. Animal and human stem cells of both embryonic and adult origin are discussed with applications ranging from nerve regeneration, orthopedics, cardiovascular therapy, blood cell generation and cancer therapy. Both synthetic and natural biomaterials are reviewed with emphasis on how material-stem cell interactions direct specific signaling pathways and ultimately modulate the cell fate. This book is valuable for biomaterial scientists, tissue engineers, clinicians as well as stem cell biologists involved in basic research and applications of adult and embryonic stem cells.87, 27a€“45 (1985) Wada, T., Honda, M., Minami, I., Tooi, N., Amagai, Y., Nakatsuji, N., Aiba, K.: Highly efficient differentiation and ... PLoS One 4(8), e6722 (2009) Langer, R., Vacanti, J.P.: Tissue engineering. ... Jiang, C.C., Tuan, R.S.: Evaluation of articular cartilage repair using biodegradable nanofibrous scaffolds in a swine model: a pilot study. ... Biomaterials 28(2), 316a€“325 (2007) Park, K., Cho, K.J., Kim, J.J., Kim, I.H., Han, D.K.: Functional PLGA scaffolds for chondrogenesis ofanbsp;...

Title:Biomaterials as Stem Cell Niche
Author:Krishnendu Roy
Publisher:Springer Science & Business Media - 2010-09-30


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