Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields. Written by international experts who have evaluated the expansive literature to provide you with one resource covering all aspects of toxicology biomarkers Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure and effect of chemicals of different classes Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation and much moreOccupational exposure to nickel was associated with increased histone 3 lysine 4 trimethylation (H3K4me3) and decreased 3 lysine 9 dimethylation (H3K9me2) ... of associations between DNA repair gene variants and cancer risk have not been replicated (Vineis et al., 2009). ... Thus, the results of GWAS may represent the basis for a comeback to a hypothesis-driven approach to biomarker discovery .
|Title||:||Biomarkers in Toxicology|
|Author||:||Ramesh C. Gupta|
|Publisher||:||Academic Press - 2014-01-25|