Annotating New Genes

Annotating New Genes

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In recent years, a number of academic and commercial software packages and databases have been developed for the analysis and screening of biological data; however, the usability of these data is compromised by so-called novel genes to which no biological function is assigned. Annotating new genes outlines an approach to the analysis of evolutionary-conserved, heart-enriched genes with unknown functions, offering a step-by-step description of the procedure from screening to validation. The book begins by offering an introduction to the databases and software available, before moving on to cover programming guidelines, including a specific case study on the use of C-It for in silico screening. The second half of the book offers a step-by-step guide to experimental validation concepts and procedures, as well as an overview of additional potential applications of this approach in the field of stem cells and tissue regeneration, before a concluding chapter summarises the concepts and theories presented. Focuses not only on screening but also on biological validations Provides details of databases and software (web interface) products for biologists with minimal computation skills Offers a step-by-step outline of the procedure involved$_ = alt;F2agt;; # make a new header line print NEW aquot;GI\tPMID\naquot;; while (defined ($f2 = alt;F2agt;)){ $f2 =~ s/\r\n/\n/; chomp ($f2); # Initialize ... If you would like to do the same with other organisms, please access the Entrez Gene FTP site (ftp://ftp.ncbi. and download the following two files: ... The Bioperl Project ( is designed to meet such demands.

Title:Annotating New Genes
Author:Shizuka Uchida
Publisher:Elsevier - 2012-08-06


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