aA comprehensive review of the recent developments in DNA repair research that have potential for translational applications. The book explains in detail the various biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK. The book captures-for both cancer researchers and oncologists dealing with hallmark qrelapseq or qdrug resistanceq phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.aCell 142(1):77a88 MacKay C, Declais AC et al (2010) Identification of KIAA1018/ FAN1, a DNA repair nuclease recruited ... H et al (2005) Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.
|Title||:||Advances in DNA Repair in Cancer Therapy|
|Author||:||Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali|
|Publisher||:||Springer Science & Business Media - 2012-12-09|